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Furthermore, if the drug compound is biologically generated, the incomplete elimination on the microorganism through purification may result in the drug material acquiring higher endotoxin concentrations.
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There is also very little recognition on the clinical importance of endotoxin. Possibly This is due to probably the most emphasized pathogenic influence of gram unfavorable disease could be the production of fever, and of all of the effects of endotoxin, fever is most likely the least critical biologically and clinically.
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With regard to producing products and transfer lines, depyrogenation by dilution has ordinarily been the method of option. Utilization of strong alkali or oxidizing Alternative has at times been employed to scale back pyrogens in these storage/delivery programs.
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